BAIT
SRPRB
APMCF1, PSEC0230
signal recognition particle receptor, B subunit
GO Process (6)
GO Function (0)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
USP16
UBP-M, UBPM, MSTP039
ubiquitin specific peptidase 16
GO Process (13)
GO Function (7)
GO Component (2)
Gene Ontology Biological Process
- cell cycle [TAS]
- cellular response to DNA damage stimulus [IDA]
- histone H2A K63-linked deubiquitination [IMP]
- histone deubiquitination [IDA]
- mitotic nuclear division [IDA]
- monoubiquitinated histone H2A deubiquitination [ISS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of translational elongation [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- protein homotetramerization [IPI]
- regulation of proteasomal protein catabolic process [IBA]
- regulation of transcription from RNA polymerase II promoter [ISS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.938962934 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.938962934, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID