TAZ
Gene Ontology Biological Process
- cardiac muscle contraction [IMP]
- cardiac muscle tissue development [IMP]
- cardiolipin acyl-chain remodeling [IBA, TAS]
- cardiolipin biosynthetic process [IMP]
- cristae formation [IMP]
- glycerophospholipid biosynthetic process [TAS]
- heart development [IMP]
- hemopoiesis [IMP]
- mitochondrial ATP synthesis coupled electron transport [IDA]
- mitochondrial respiratory chain complex I assembly [IMP]
- muscle contraction [IMP]
- phospholipid metabolic process [TAS]
- skeletal muscle tissue development [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NRP2
Gene Ontology Biological Process
- angiogenesis [NAS]
- axon extension involved in axon guidance [ISS]
- axon guidance [NAS, TAS]
- cell adhesion [NAS]
- nerve development [ISS]
- positive regulation of endothelial cell migration [TAS]
- positive regulation of endothelial cell proliferation [TAS]
- semaphorin-plexin signaling pathway involved in neuron projection guidance [ISS]
- sympathetic ganglion development [ISS]
- sympathetic neuron projection extension [ISS]
- sympathetic neuron projection guidance [ISS]
- vascular endothelial growth factor receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.935404418 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.935404418, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| TAZ NRP2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8687 | BioGRID | 1178412 | |
| TAZ NRP2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.7827 | BioGRID | 3111924 |
Curated By
- BioGRID