BAIT
CHRM4
HM4, M4R
cholinergic receptor, muscarinic 4
GO Process (4)
GO Function (0)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
PREY
ATP5B
ATPMB, ATPSB, HEL-S-271
ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide
GO Process (11)
GO Function (6)
GO Component (11)
Gene Ontology Biological Process
- ATP biosynthetic process [IMP]
- ATP catabolic process [IDA]
- angiogenesis [IMP]
- cellular metabolic process [TAS]
- generation of precursor metabolites and energy [NAS]
- mitochondrial ATP synthesis coupled proton transport [IC, TAS]
- osteoblast differentiation [IDA]
- proton transport [IMP]
- regulation of intracellular pH [IMP]
- respiratory electron transport chain [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cell surface [IDA]
- extracellular vesicular exosome [IDA]
- membrane [IDA]
- mitochondrial matrix [NAS, TAS]
- mitochondrial membrane [IDA]
- mitochondrial nucleoid [IDA]
- mitochondrial proton-transporting ATP synthase complex [IDA]
- mitochondrial proton-transporting ATP synthase, catalytic core [NAS]
- mitochondrion [IDA]
- nucleus [IDA]
- plasma membrane [IDA]
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.934316185 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.934316185, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID