CER1
Gene Ontology Biological Process
- BMP signaling pathway [TAS]
- anterior/posterior axis specification [ISS]
- anterior/posterior pattern specification [ISS]
- bone mineralization [IMP]
- cell migration involved in gastrulation [ISS]
- cellular response to BMP stimulus [ISS]
- determination of dorsal identity [IMP]
- gastrulation [ISS]
- growth plate cartilage chondrocyte proliferation [ISS]
- negative regulation of BMP signaling pathway [ISS]
- negative regulation of Wnt signaling pathway [ISS]
- negative regulation of activin receptor signaling pathway [IDA, ISS]
- negative regulation of cell proliferation [ISS]
- negative regulation of mesoderm development [IMP, ISS]
- nervous system development [IMP]
- sequestering of BMP in extracellular matrix [IDA, ISS]
- signal transduction involved in regulation of gene expression [ISS]
- ureteric bud development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
VHL
Gene Ontology Biological Process
- cell morphogenesis [NAS]
- cellular response to hypoxia [TAS]
- negative regulation of apoptotic process [NAS]
- negative regulation of cell proliferation [TAS]
- negative regulation of transcription from RNA polymerase II promoter [TAS]
- negative regulation of transcription from RNA polymerase II promoter in response to hypoxia [IDA]
- positive regulation of cell differentiation [NAS]
- positive regulation of transcription, DNA-templated [IMP]
- protein stabilization [NAS]
- protein ubiquitination [IDA, IMP]
- proteolysis [TAS]
- regulation of transcription from RNA polymerase II promoter in response to hypoxia [TAS]
- regulation of transcription, DNA-templated [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.930887324 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.930887324, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
CER1 VHL | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9722 | BioGRID | 1178646 |
Curated By
- BioGRID