BAIT
CLEC4M
CD209L, CD299, DC-SIGN2, DC-SIGNR, DCSIGNR, HP10347, L-SIGN, LSIGN
C-type lectin domain family 4, member M
GO Process (11)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- antigen processing and presentation [NAS]
- cell-cell recognition [TAS]
- intracellular signal transduction [NAS]
- intracellular transport of virus [TAS]
- leukocyte cell-cell adhesion [NAS]
- modulation by virus of host morphology or physiology [TAS]
- peptide antigen transport [NAS]
- regulation of blood coagulation [IMP]
- regulation of gene expression [IMP]
- viral genome replication [NAS]
- virion attachment to host cell [TAS]
Gene Ontology Molecular Function
Homo sapiens
PREY
GFAP
glial fibrillary acidic protein
GO Process (0)
GO Function (0)
GO Component (2)
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.924949916 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.924949916, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID