IFNG
Gene Ontology Biological Process
- adaptive immune response [IBA]
- apoptotic process [IGI]
- cell cycle arrest [IDA]
- cell surface receptor signaling pathway [TAS]
- cellular component movement [TAS]
- cytokine-mediated signaling pathway [TAS]
- extrinsic apoptotic signaling pathway [IDA]
- humoral immune response [IBA]
- interferon-gamma-mediated signaling pathway [TAS]
- negative regulation of epithelial cell differentiation [ISS]
- negative regulation of interleukin-17 production [IDA]
- negative regulation of smooth muscle cell proliferation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of calcidiol 1-monooxygenase activity [IDA]
- positive regulation of cell proliferation [ISS]
- positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity [IDA]
- positive regulation of fructose 1,6-bisphosphate metabolic process [IDA]
- positive regulation of interleukin-12 production [IDA]
- positive regulation of interleukin-23 production [IDA]
- positive regulation of killing of cells of other organism [IDA]
- positive regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of osteoclast differentiation [IDA]
- positive regulation of peptidyl-serine phosphorylation of STAT protein [IDA, NAS]
- positive regulation of smooth muscle cell apoptotic process [IDA]
- positive regulation of tumor necrosis factor (ligand) superfamily member 11 production [IDA]
- positive regulation of tyrosine phosphorylation of Stat1 protein [IDA]
- positive regulation of vitamin D biosynthetic process [IDA]
- protein import into nucleus, translocation [IDA]
- regulation of insulin secretion [IDA]
- regulation of interferon-gamma-mediated signaling pathway [TAS]
- response to virus [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
GOPC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.920643046 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.920643046, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| IFNG GOPC | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9599 | BioGRID | 3053325 |
Curated By
- BioGRID