MAPK8IP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
SETX
Gene Ontology Biological Process
- DNA duplex unwinding [TAS]
- MAPK cascade [IDA]
- RNA processing [TAS]
- cellular response to DNA damage stimulus [IDA]
- cellular response to fibroblast growth factor stimulus [IDA]
- cellular response to hydrogen peroxide [IDA]
- cellular response to oxidative stress [IDA]
- cellular response to retinoic acid [IDA]
- double-strand break repair [IDA]
- fibroblast growth factor receptor signaling pathway [IDA]
- mRNA splice site selection [IMP]
- negative regulation of apoptotic process [IDA]
- positive regulation of DNA-templated transcription, initiation [IMP]
- positive regulation of DNA-templated transcription, termination [IMP]
- positive regulation of RNA splicing [IMP]
- positive regulation of neuron projection development [IDA]
- positive regulation of termination of RNA polymerase II transcription, poly(A)-coupled [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein kinase B signaling [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.903986236 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.903986236, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
MAPK8IP1 SETX | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9389 | BioGRID | 3129822 |
Curated By
- BioGRID