BAIT
WNT16
wingless-type MMTV integration site family, member 16
GO Process (12)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
- Wnt signaling pathway [IBA]
- cell fate commitment [IBA]
- keratinocyte differentiation [IMP]
- keratinocyte proliferation [IMP]
- negative regulation of cell death [IMP]
- neuron differentiation [IBA]
- optic cup formation involved in camera-type eye development [ISS]
- oxidative stress-induced premature senescence [IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of gene expression [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- replicative senescence [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
CANX
CNX, IP90, P90
calnexin
GO Process (9)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- antigen processing and presentation of peptide antigen via MHC class I [TAS]
- cellular protein metabolic process [TAS]
- clathrin-mediated endocytosis [ISS]
- post-translational protein modification [TAS]
- protein N-linked glycosylation via asparagine [TAS]
- protein folding [TAS]
- protein secretion [TAS]
- synaptic vesicle endocytosis [ISS]
Gene Ontology Molecular Function
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.901689267 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.901689267, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID