BAIT
RFX3
RP11-32F11.1
regulatory factor X, 3 (influences HLA class II expression)
GO Process (14)
GO Function (6)
GO Component (3)
Gene Ontology Biological Process
- cell maturation [ISS]
- cilium assembly [IBA, ISS]
- cilium-dependent cell motility [ISS]
- endocrine pancreas development [ISS]
- epithelial cilium movement involved in determination of left/right asymmetry [ISS]
- negative regulation of transcription, DNA-templated [IDA]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of type B pancreatic cell development [ISS]
- regulation of insulin secretion [ISS]
- regulation of transcription from RNA polymerase II promoter [IBA]
- regulation of transcription, DNA-templated [ISS]
- transcription from RNA polymerase II promoter [TAS]
- type B pancreatic cell differentiation [IBA]
Gene Ontology Molecular Function- DNA binding [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IBA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [TAS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription regulatory region DNA binding [IDA]
- DNA binding [TAS]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IBA]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [TAS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription regulatory region DNA binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
IGSF8
CD316, CD81P3, EWI-2, EWI2, KCT-4, LIR-D1, PGRL, RP11-536C5.3
immunoglobulin superfamily, member 8
GO Process (5)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.896332907 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.896332907, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID