CDH13
Gene Ontology Biological Process
- Rac protein signal transduction [IMP]
- Rho protein signal transduction [IMP]
- adherens junction organization [TAS]
- calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- cell junction assembly [TAS]
- cell-cell junction organization [TAS]
- endothelial cell migration [IDA]
- homophilic cell adhesion via plasma membrane adhesion molecules [IDA]
- keratinocyte proliferation [IDA]
- lamellipodium assembly [IDA]
- localization within membrane [IMP]
- low-density lipoprotein particle mediated signaling [IDA]
- negative regulation of cell adhesion [IDA]
- negative regulation of cell proliferation [IDA]
- positive regulation of calcium-mediated signaling [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of cell-matrix adhesion [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of positive chemotaxis [IDA]
- positive regulation of smooth muscle cell proliferation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- regulation of endocytosis [IMP]
- regulation of epidermal growth factor receptor signaling pathway [IMP]
- sprouting angiogenesis [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TUBB3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.895263365 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.895263365, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
CDH13 TUBB3 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.7604 | BioGRID | 3046226 |
Curated By
- BioGRID