CD4
Gene Ontology Biological Process
- T cell costimulation [TAS]
- T cell differentiation [IDA]
- T cell receptor signaling pathway [TAS]
- T cell selection [IDA]
- cell surface receptor signaling pathway [TAS]
- entry into host cell [TAS]
- enzyme linked receptor protein signaling pathway [TAS]
- immune response [NAS]
- induction by virus of host cell-cell fusion [IDA]
- innate immune response [TAS]
- maintenance of protein location in cell [IDA]
- positive regulation of interleukin-2 biosynthetic process [NAS]
- positive regulation of protein kinase activity [IDA]
- protein palmitoleylation [IDA]
- regulation of T cell activation [IDA]
- regulation of defense response to virus by virus [TAS]
- signal transduction [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [NAS]
- viral process [TAS]
Gene Ontology Molecular Function- MHC class II protein binding [NAS]
- coreceptor activity [NAS]
- enzyme binding [IPI]
- extracellular matrix structural constituent [NAS]
- glycoprotein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [IPI]
- receptor activity [TAS]
- transmembrane signaling receptor activity [TAS]
- zinc ion binding [IDA]
- MHC class II protein binding [NAS]
- coreceptor activity [NAS]
- enzyme binding [IPI]
- extracellular matrix structural constituent [NAS]
- glycoprotein binding [IPI]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- protein kinase binding [IPI]
- receptor activity [TAS]
- transmembrane signaling receptor activity [TAS]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
ATP6V0A1
Gene Ontology Biological Process
- ATP synthesis coupled proton transport [IBA]
- cellular iron ion homeostasis [TAS]
- insulin receptor signaling pathway [TAS]
- interaction with host [TAS]
- phagosome maturation [TAS]
- transferrin transport [TAS]
- transmembrane transport [TAS]
- vacuolar acidification [IBA]
- vacuolar proton-transporting V-type ATPase complex assembly [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.879716363 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.879716363, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
CD4 ATP6V0A1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8516 | BioGRID | 3132506 |
Curated By
- BioGRID