BAIT
ADAMTS12
PRO4389, UNQ1918
ADAM metallopeptidase with thrombospondin type 1 motif, 12
GO Process (13)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
- cell migration [IMP]
- cell-matrix adhesion [IMP]
- cellular response to BMP stimulus [IDA]
- cellular response to interleukin-1 [IMP]
- cellular response to tumor necrosis factor [IMP]
- negative regulation of cellular response to hepatocyte growth factor stimulus [IDA]
- negative regulation of cellular response to vascular endothelial growth factor stimulus [IDA]
- negative regulation of chondrocyte differentiation [IDA]
- negative regulation of hepatocyte growth factor receptor signaling pathway [IDA]
- proteoglycan catabolic process [IDA]
- proteolysis involved in cellular protein catabolic process [IDA, IMP]
- regulation of endothelial tube morphogenesis [IDA]
- regulation of inflammatory response [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
RUFY3
RIPX, SINGAR1
RUN and FYVE domain containing 3
GO Process (1)
GO Function (0)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.879645309 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.879645309, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID