BAIT
ATP2B2
PMCA2, PMCA2a, PMCA2i
ATPase, Ca++ transporting, plasma membrane 2
GO Process (9)
GO Function (7)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC26A6
solute carrier family 26 (anion exchanger), member 6
GO Process (25)
GO Function (11)
GO Component (9)
Gene Ontology Biological Process
- angiotensin-activated signaling pathway [IDA]
- anion transport [IDA]
- bicarbonate transport [IDA, IMP]
- cellular response to cAMP [ISS]
- cellular response to fructose stimulus [ISS]
- cellular response to interferon-gamma [IDA]
- chloride transmembrane transport [IDA, IMP, ISS]
- chloride transport [IDA, IMP]
- epithelial fluid transport [ISS]
- formate transport [ISS]
- intestinal absorption [ISS]
- intracellular pH elevation [ISS]
- ion transport [TAS]
- mannitol transport [ISS]
- oxalate transport [IMP, ISS]
- oxalic acid secretion [ISS]
- positive regulation of dipeptide transmembrane transport [ISS]
- protein kinase C signaling [IDA]
- regulation of intracellular pH [IDA, IMP]
- sperm capacitation [ISS]
- sulfate transmembrane transport [IDA, IMP]
- sulfate transport [IMP, ISS]
- transepithelial chloride transport [IMP, ISS]
- transepithelial transport [ISS]
- transmembrane transport [TAS]
Gene Ontology Molecular Function- PDZ domain binding [ISS]
- anion:anion antiporter activity [IDA, IMP, ISS]
- bicarbonate transmembrane transporter activity [IDA, IMP, ISS]
- chloride transmembrane transporter activity [IDA, IMP, ISS]
- efflux transmembrane transporter activity [ISS]
- formate efflux transmembrane transporter activity [ISS]
- formate transmembrane transporter activity [ISS]
- formate uptake transmembrane transporter activity [ISS]
- oxalate transmembrane transporter activity [IMP]
- protein binding [IPI]
- sulfate transmembrane transporter activity [IDA, IMP]
- PDZ domain binding [ISS]
- anion:anion antiporter activity [IDA, IMP, ISS]
- bicarbonate transmembrane transporter activity [IDA, IMP, ISS]
- chloride transmembrane transporter activity [IDA, IMP, ISS]
- efflux transmembrane transporter activity [ISS]
- formate efflux transmembrane transporter activity [ISS]
- formate transmembrane transporter activity [ISS]
- formate uptake transmembrane transporter activity [ISS]
- oxalate transmembrane transporter activity [IMP]
- protein binding [IPI]
- sulfate transmembrane transporter activity [IDA, IMP]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.878424929 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.878424929, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID