SNX9
Gene Ontology Biological Process
- cleavage furrow formation [IMP]
- endocytosis [IMP]
- endosomal transport [IMP]
- intracellular protein transport [IMP]
- lipid tube assembly [IDA]
- membrane tubulation [IDA]
- mitotic cytokinesis [IMP]
- positive regulation of GTPase activity [IDA]
- positive regulation of membrane protein ectodomain proteolysis [IDA]
- positive regulation of protein kinase activity [IDA]
- positive regulation of protein oligomerization [IDA]
- receptor-mediated endocytosis [IMP]
- vesicle organization [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
AP2B1
Gene Ontology Biological Process
- antigen processing and presentation of exogenous peptide antigen via MHC class II [TAS]
- axon guidance [TAS]
- clathrin-mediated endocytosis [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- negative regulation of epidermal growth factor receptor signaling pathway [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- regulation of defense response to virus by virus [TAS]
- synaptic transmission [TAS]
- viral process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.870636859 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.870636859, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
AP2B1 SNX9 | Proximity Label-MS Proximity Label-MS An interaction is inferred when a bait-enzyme fusion protein selectively modifies a vicinal protein with a diffusible reactive product, followed by affinity capture of the modified protein and identification by mass spectrometric methods. | High | 7.66 | BioGRID | 2979295 |
Curated By
- BioGRID