DDHD2
Gene Ontology Cellular Component
CHI3L1
Gene Ontology Biological Process
- activation of NF-kappaB-inducing kinase activity [ISS]
- cartilage development [NAS]
- cellular response to tumor necrosis factor [ISS]
- chitin catabolic process [IBA]
- immune response [IBA]
- inflammatory response [IEP]
- interleukin-8 secretion [ISS]
- lung development [IMP]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of angiogenesis [IMP]
- positive regulation of peptidyl-threonine phosphorylation [ISS]
- positive regulation of protein kinase B signaling [IMP]
- response to interleukin-1 [IEP]
- response to interleukin-6 [IEP]
- response to mechanical stimulus [IEP]
- response to tumor necrosis factor [IEP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.869952532 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.869952532, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| DDHD2 CHI3L1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9863 | BioGRID | 3052914 |
Curated By
- BioGRID