PLK2
Gene Ontology Biological Process
- G1/S transition of mitotic cell cycle [IMP]
- Rap protein signal transduction [ISS]
- Ras protein signal transduction [ISS]
- long term synaptic depression [ISS]
- long-term synaptic potentiation [ISS]
- memory [ISS]
- mitotic cell cycle checkpoint [ISS]
- mitotic spindle organization [IDA]
- negative regulation of apoptotic process [ISS]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- protein phosphorylation [IDA]
- regulation of centriole replication [IDA, IMP]
- regulation of synaptic plasticity [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CTSV
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.863349572 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.863349572, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| PLK2 CTSV | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8463 | BioGRID | 1198311 | |
| PLK2 CTSV | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8472 | BioGRID | 3094618 |
Curated By
- BioGRID