BAIT
MADCAM1
MACAM1
mucosal vascular addressin cell adhesion molecule 1
GO Process (10)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- cell adhesion [TAS]
- cell-matrix adhesion [IDA]
- extracellular matrix organization [TAS]
- heterotypic cell-cell adhesion [IMP]
- immune response [TAS]
- integrin-mediated signaling pathway [IDA]
- leukocyte tethering or rolling [IDA]
- receptor clustering [IDA]
- regulation of immune response [TAS]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ARFGEF2
BIG2, PVNH2, dJ1164I10.1
ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
GO Process (8)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- Golgi to plasma membrane transport [IMP]
- endomembrane system organization [IMP]
- endosome organization [IMP]
- intracellular signal transduction [IDA]
- positive regulation of GTPase activity [IBA, IDA]
- positive regulation of tumor necrosis factor production [IMP]
- receptor recycling [IDA]
- vesicle-mediated transport [IBA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.842975831 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.842975831, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID