BAIT
HYAL1
HYAL-1, LUCA1, NAT6
hyaluronoglucosaminidase 1
GO Process (27)
GO Function (4)
GO Component (7)
Gene Ontology Biological Process
- carbohydrate metabolic process [TAS]
- cartilage development [IEP]
- cellular response to UV-B [IDA]
- cellular response to fibroblast growth factor stimulus [IDA]
- cellular response to interleukin-1 [IDA]
- cellular response to pH [IDA]
- cellular response to platelet-derived growth factor stimulus [IDA]
- cellular response to tumor necrosis factor [IEP]
- chondroitin sulfate catabolic process [TAS]
- chondroitin sulfate metabolic process [TAS]
- glycosaminoglycan metabolic process [TAS]
- hyaluronan biosynthetic process [IDA]
- hyaluronan catabolic process [IDA, TAS]
- hyaluronan metabolic process [IDA, TAS]
- inflammatory response [IDA]
- negative regulation of cell growth [IDA]
- positive regulation of angiogenesis [IDA, IMP]
- positive regulation of cell adhesion [IMP]
- positive regulation of cell growth [IMP]
- positive regulation of epithelial cell migration [IDA]
- positive regulation of epithelial cell proliferation [IDA]
- positive regulation of growth [IDA]
- positive regulation of hyaluranon cable assembly [IDA]
- response to antibiotic [IDA]
- response to reactive oxygen species [IDA]
- response to virus [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
TUBA4A
H2-ALPHA, TUBA1
tubulin, alpha 4a
GO Process (8)
GO Function (1)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.826827995 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.826827995, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID