BAIT
PRKAG2
AAKG, AAKG2, CMH6, H91620p, WPWS
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
GO Process (20)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
- ATP biosynthetic process [TAS]
- carnitine shuttle [TAS]
- cell cycle arrest [TAS]
- cellular lipid metabolic process [TAS]
- energy reserve metabolic process [TAS]
- glycogen metabolic process [IMP]
- insulin receptor signaling pathway [TAS]
- intracellular signal transduction [IMP]
- membrane organization [TAS]
- negative regulation of protein kinase activity [IDA]
- negative regulation of protein serine/threonine kinase activity [IDA]
- positive regulation of peptidyl-threonine phosphorylation [IMP]
- positive regulation of protein kinase activity [IMP]
- regulation of fatty acid biosynthetic process [TAS]
- regulation of fatty acid metabolic process [IMP]
- regulation of fatty acid oxidation [TAS]
- regulation of glucose import [TAS]
- regulation of glycolytic process [IMP]
- small molecule metabolic process [TAS]
- sterol biosynthetic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
NEFH
NFH
neurofilament, heavy polypeptide
GO Process (5)
GO Function (7)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.813579932 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.813579932, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID