BAIT
LPAR1
EDG2, GPR26, Gpcr26, LPA1, Mrec1.3, VZG1, edg-2, rec.1.3, vzg-1, RP11-104M22.2
lysophosphatidic acid receptor 1
GO Process (4)
GO Function (2)
GO Component (4)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
COL1A1
OI4
collagen, type I, alpha 1
GO Process (20)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- blood coagulation [TAS]
- blood vessel development [IMP]
- collagen biosynthetic process [IMP]
- collagen catabolic process [TAS]
- collagen fibril organization [IMP]
- embryonic skeletal system development [IMP]
- extracellular matrix disassembly [TAS]
- extracellular matrix organization [TAS]
- leukocyte migration [TAS]
- platelet activation [TAS]
- positive regulation of canonical Wnt signaling pathway [IDA]
- positive regulation of cell migration [IDA]
- positive regulation of epithelial to mesenchymal transition [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- protein localization to nucleus [IDA]
- sensory perception of sound [IMP]
- skeletal system development [IMP]
- skin morphogenesis [IMP]
- tooth mineralization [IMP]
- visual perception [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.783919823 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.783919823, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID