APOD
Gene Ontology Biological Process
- aging [NAS]
- angiogenesis [NAS]
- brain development [ISS]
- glucose metabolic process [IDA]
- lipid metabolic process [IDA]
- lipid transport [NAS]
- negative regulation of T cell migration [IDA]
- negative regulation of cytokine production involved in inflammatory response [IDA]
- negative regulation of focal adhesion assembly [IMP]
- negative regulation of lipoprotein lipid oxidation [IDA]
- negative regulation of monocyte chemotactic protein-1 production [IDA]
- negative regulation of platelet-derived growth factor receptor signaling pathway [IDA]
- negative regulation of protein import into nucleus [IDA]
- negative regulation of smooth muscle cell proliferation [IDA]
- negative regulation of smooth muscle cell-matrix adhesion [IMP]
- peripheral nervous system axon regeneration [ISS]
- response to axon injury [ISS]
- response to drug [ISS]
- response to reactive oxygen species [IDA]
- tissue regeneration [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
TOR1A
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- ER-associated misfolded protein catabolic process [ISS]
- cell adhesion [IMP]
- chaperone-mediated protein folding [IDA]
- chaperone-mediated protein transport [IDA]
- intermediate filament cytoskeleton organization [IMP]
- neuron projection development [IMP]
- nuclear envelope organization [ISS]
- nuclear membrane organization [ISS]
- organelle organization [ISS]
- positive regulation of synaptic vesicle endocytosis [IMP]
- protein deneddylation [IMP]
- protein homooligomerization [IDA]
- protein localization to nucleus [IMP, ISS]
- regulation of dopamine uptake involved in synaptic transmission [IDA]
- regulation of protein localization to cell surface [IMP]
- synaptic vesicle transport [IMP]
- wound healing, spreading of cells [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- cytoplasmic vesicle membrane [ISS]
- endoplasmic reticulum lumen [IDA]
- extracellular vesicular exosome [IDA]
- extrinsic component of endoplasmic reticulum membrane [IDA]
- growth cone [ISS]
- intracellular membrane-bounded organelle [IDA]
- membrane [IDA]
- nuclear envelope [ISS]
- nuclear membrane [IDA]
- secretory granule [ISS]
- synaptic vesicle [IDA]
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.780036497 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.780036497, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
APOD TOR1A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8924 | BioGRID | 3050941 |
Curated By
- BioGRID