BAIT
SLC1A1
DCBXA, EAAC1, EAAT3, SCZD18, RP11-6J24.1
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1
GO Process (7)
GO Function (2)
GO Component (5)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SLC25A17
PMP34, RP3-362J20.2
solute carrier family 25 (mitochondrial carrier; peroxisomal membrane protein, 34kDa), member 17
GO Process (12)
GO Function (9)
GO Component (5)
Gene Ontology Biological Process
- ADP transport [IDA]
- AMP transport [IDA]
- ATP transport [IGI]
- FAD transmembrane transport [IDA]
- NAD transport [IDA]
- cellular lipid metabolic process [TAS]
- coenzyme A transmembrane transport [IDA]
- fatty acid alpha-oxidation [TAS]
- fatty acid beta-oxidation [IGI]
- fatty acid transport [IGI]
- nucleotide transmembrane transport [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function- ADP transmembrane transporter activity [IDA]
- AMP transmembrane transporter activity [IDA]
- ATP transmembrane transporter activity [IGI]
- FAD transmembrane transporter activity [IDA]
- FMN transmembrane transporter activity [IDA]
- NAD transporter activity [IDA]
- chaperone binding [IPI]
- coenzyme A transmembrane transporter activity [IDA]
- protein binding [IPI]
- ADP transmembrane transporter activity [IDA]
- AMP transmembrane transporter activity [IDA]
- ATP transmembrane transporter activity [IGI]
- FAD transmembrane transporter activity [IDA]
- FMN transmembrane transporter activity [IDA]
- NAD transporter activity [IDA]
- chaperone binding [IPI]
- coenzyme A transmembrane transporter activity [IDA]
- protein binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.778608877 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.778608877, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID