BAIT
USP47
TRFP
ubiquitin specific peptidase 47
GO Process (12)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- base-excision repair [IMP]
- cellular response to DNA damage stimulus [IMP]
- cellular response to UV [ISS]
- monoubiquitinated protein deubiquitination [IDA]
- negative regulation of G2/M transition of mitotic cell cycle [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cysteine-type endopeptidase activity involved in apoptotic process [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of cell growth [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IBA]
- regulation of proteasomal protein catabolic process [IBA]
- response to drug [IMP]
Gene Ontology Molecular Function
Homo sapiens
PREY
EEA1
MST105, MSTP105, ZFYVE2
early endosome antigen 1
GO Process (4)
GO Function (6)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.775717104 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.775717104, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID