BAIT
CHRM3
EGBRS, HM3
cholinergic receptor, muscarinic 3
GO Process (9)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- G-protein coupled acetylcholine receptor signaling pathway [ISS]
- G-protein coupled receptor signaling pathway [TAS]
- cell proliferation [TAS]
- cellular protein modification process [TAS]
- energy reserve metabolic process [TAS]
- nervous system development [TAS]
- regulation of insulin secretion [TAS]
- signal transduction [TAS]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
FLT4
FLT41, LMPH1A, PCL, VEGFR3
fms-related tyrosine kinase 4
GO Process (22)
GO Function (5)
GO Component (2)
Gene Ontology Biological Process
- blood vessel morphogenesis [ISS]
- cellular response to vascular endothelial growth factor stimulus [IDA, IMP]
- lymph vessel development [ISS]
- lymphangiogenesis [IMP, ISS]
- negative regulation of apoptotic process [IMP]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of ERK1 and ERK2 cascade [IMP]
- positive regulation of JNK cascade [IMP]
- positive regulation of MAPK cascade [IMP]
- positive regulation of cell proliferation [IGI, IMP]
- positive regulation of endothelial cell migration [IMP]
- positive regulation of endothelial cell proliferation [IMP]
- positive regulation of protein kinase C signaling [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation vascular endothelial growth factor production [IMP]
- protein autophosphorylation [IDA]
- regulation of blood vessel remodeling [ISS]
- sprouting angiogenesis [ISS]
- transmembrane receptor protein tyrosine kinase signaling pathway [TAS]
- vascular endothelial growth factor receptor signaling pathway [IDA, IGI, IMP, TAS]
- vascular endothelial growth factor signaling pathway [IDA, IMP, TAS]
- vasculature development [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.775641913 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.775641913, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID