BAIT
FGF8
AIGF, FGF-8, HBGF-8, HH6, KAL6
fibroblast growth factor 8 (androgen-induced)
GO Process (20)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- anatomical structure morphogenesis [NAS]
- bone development [IMP]
- dopaminergic neuron differentiation [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- epithelial to mesenchymal transition involved in endocardial cushion formation [ISS]
- fibroblast growth factor receptor signaling pathway [IGI, TAS]
- gastrulation [NAS]
- gonad development [IMP]
- innate immune response [TAS]
- insulin receptor signaling pathway [TAS]
- mesonephros development [IEP]
- metanephros development [IEP]
- negative regulation of cardiac muscle tissue development [IMP]
- neuroepithelial cell differentiation [IDA]
- neurotrophin TRK receptor signaling pathway [TAS]
- odontogenesis [IEP]
- outflow tract septum morphogenesis [ISS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of cell proliferation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
UPF1
HUPF1, NORF1, RENT1, pNORF1, smg-2
UPF1 regulator of nonsense transcripts homolog (yeast)
GO Process (11)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- ATP catabolic process [IDA]
- DNA repair [IDA]
- DNA replication [IMP]
- RNA metabolic process [TAS]
- gene expression [TAS]
- histone mRNA catabolic process [IMP]
- mRNA export from nucleus [TAS]
- mRNA metabolic process [TAS]
- nuclear-transcribed mRNA catabolic process [IMP]
- nuclear-transcribed mRNA catabolic process, nonsense-mediated decay [IDA, IMP, NAS, TAS]
- regulation of translational termination [IMP, NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Nature May. 25, 2017; 545(7655);505-509 [Pubmed: 28514442]
Quantitative Score
- 0.755279261 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.755279261, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Curated By
- BioGRID