VCAM1
Gene Ontology Biological Process
- B cell differentiation [IC]
- amine metabolic process [IDA]
- cell adhesion [IDA]
- cell-matrix adhesion [IDA]
- cytokine-mediated signaling pathway [TAS]
- extracellular matrix organization [TAS]
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules [IDA]
- interferon-gamma-mediated signaling pathway [TAS]
- leukocyte cell-cell adhesion [IDA]
- leukocyte tethering or rolling [IDA, IEP]
- membrane to membrane docking [IEP]
- oxidation-reduction process [IDA]
- positive regulation of T cell proliferation [IDA]
- regulation of immune response [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex [IDA]
- apical part of cell [IDA]
- cell surface [IDA]
- early endosome [IDA]
- endoplasmic reticulum [IDA]
- external side of plasma membrane [IDA]
- extracellular space [IDA]
- extracellular vesicular exosome [IDA]
- filopodium [IDA]
- microvillus [IDA]
- plasma membrane [TAS]
- podosome [IDA]
TUBA4A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.754681962 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.754681962, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| VCAM1 TUBA4A | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8766 | BioGRID | 3133144 |
Curated By
- BioGRID