MLF1
Gene Ontology Biological Process
Gene Ontology Molecular Function
RIPK1
Gene Ontology Biological Process
- MyD88-independent toll-like receptor signaling pathway [TAS]
- T cell apoptotic process [ISS]
- TRIF-dependent toll-like receptor signaling pathway [TAS]
- activation of JUN kinase activity [TAS]
- activation of cysteine-type endopeptidase activity involved in apoptotic process [TAS]
- amyloid fibril formation [IMP]
- apoptotic process [IMP, TAS]
- apoptotic signaling pathway [TAS]
- cellular protein catabolic process [IDA]
- cellular response to tumor necrosis factor [IDA]
- extrinsic apoptotic signaling pathway [IDA, IMP]
- innate immune response [TAS]
- necroptotic process [IMP]
- necroptotic signaling pathway [IMP, ISS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IMP]
- negative regulation of extrinsic apoptotic signaling pathway [IMP]
- peptidyl-serine autophosphorylation [IDA]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IDA, IEP]
- positive regulation of JNK cascade [IDA]
- positive regulation of NF-kappaB transcription factor activity [IMP]
- positive regulation of apoptotic process [IDA, IMP]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of interleukin-8 production [IDA]
- positive regulation of macrophage differentiation [IMP]
- positive regulation of necroptotic process [IMP]
- positive regulation of programmed cell death [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of reactive oxygen species metabolic process [TAS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of tumor necrosis factor production [IDA]
- positive regulation of type I interferon production [TAS]
- protein autophosphorylation [IDA]
- protein heterooligomerization [IMP]
- protein homooligomerization [IDA]
- regulation of ATP:ADP antiporter activity [IMP]
- regulation of extrinsic apoptotic signaling pathway in absence of ligand [TAS]
- response to tumor necrosis factor [IMP]
- ripoptosome assembly [IMP]
- toll-like receptor 3 signaling pathway [TAS]
- toll-like receptor 4 signaling pathway [TAS]
- toll-like receptor signaling pathway [TAS]
- tumor necrosis factor-mediated signaling pathway [IC]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.754502572 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.754502572, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
MLF1 RIPK1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.9311 | BioGRID | 1178912 | |
MLF1 RIPK1 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8931 | BioGRID | 3110959 |
Curated By
- BioGRID