BBS7
Gene Ontology Biological Process
- cilium morphogenesis [ISS]
- determination of left/right symmetry [ISS]
- digestive tract morphogenesis [ISS]
- fat cell differentiation [ISS]
- heart looping [ISS]
- melanosome transport [ISS]
- pigment granule aggregation in cell center [ISS]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IPI]
- regulation of transcription from RNA polymerase II promoter [IPI]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- BBSome [IDA]
- centrosome [IDA]
KANK2
Gene Ontology Biological Process
- negative regulation of G1/S transition of mitotic cell cycle [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of intracellular estrogen receptor signaling pathway [IDA]
- negative regulation of programmed cell death [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
Architecture of the human interactome defines protein communities and disease networks.
The physiology of a cell can be viewed as the product of thousands of proteins acting in concert to shape the cellular response. Coordination is achieved in part through networks of protein-protein interactions that assemble functionally related proteins into complexes, organelles, and signal transduction pathways. Understanding the architecture of the human proteome has the potential to inform cellular, structural, and ... [more]
Quantitative Score
- 0.750504784 [compPASS Score]
Throughput
- High Throughput
Additional Notes
- BioPlex 2.0 HEK 293T cells CompPASS score = 0.750504784, threshold = 0.75. Quantitative scores calculated by CompPASS-Plus (Huttlin et al. Cell, 2015, PMID: 26186194).
- See BioPlex Interactome for details (https://bioplex.hms.harvard.edu/index.php).
- This data has also been reanalyzed as part of BioPlex 3.0 (PMID: 33961781) and may be re-scored from BioPlex 1.0 (PMID: 26186194). Only scores from within BioPlex 2.0 (PMID: 28514442) should be compared directly.
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| BBS7 KANK2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | 0.8037 | BioGRID | 3070317 |
Curated By
- BioGRID