BAIT

PTPRO

GLEPP1, NPHS6, PTP-OC, PTP-U2, PTPROT, PTPU2, R-PTP-O
protein tyrosine phosphatase, receptor type, O
Homo sapiens
PREY

TXNDC12

AG1, AGR1, ERP16, ERP18, ERP19, PDIA16, TLP19, hAG-1, hTLP19, UNQ713/PRO1376
thioredoxin domain containing 12 (endoplasmic reticulum)
GO Process (0)
GO Function (0)
GO Component (0)
Homo sapiens

Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.

Publication

Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family.

Li X, Tran KM, Aziz KE, Sorokin AV, Chen J, Wang W

Protein tyrosine phosphorylation, which plays a vital role in a variety of human cellular processes, is coordinated by protein tyrosine kinases and protein tyrosine phosphatases (PTPs). Genomic studies provide compelling evidence that PTPs are frequently mutated in various human cancers, suggesting that they have important roles in tumor suppression. However, the cellular functions and regulatory machineries of most PTPs are ... [more]

Mol. Cell Proteomics Sep. 01, 2016; 15(9);3030-44 [Pubmed: 27432908]

Throughput

  • High Throughput

Additional Notes

  • high-confidence candidate interacting protein

Curated By

  • BioGRID