BAIT
NRG1
ARIA, GGF, GGF2, HGL, HRG, HRG1, HRGA, MST131, MSTP131, NDF, NRG1-IT2, SMDF
neuregulin 1
GO Process (33)
GO Function (9)
GO Component (4)
Gene Ontology Biological Process
- ERBB signaling pathway [IDA]
- Fc-epsilon receptor signaling pathway [TAS]
- activation of transmembrane receptor protein tyrosine kinase activity [IDA, NAS]
- cardiac muscle cell differentiation [ISS]
- cardiac muscle cell myoblast differentiation [IDA]
- cell communication [TAS]
- cell proliferation [IDA]
- cellular protein complex disassembly [IGI]
- endocardial cell differentiation [IDA]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- intracellular signal transduction [IBA]
- mammary gland development [TAS]
- negative regulation of cardiac muscle cell apoptotic process [IDA]
- negative regulation of extrinsic apoptotic signaling pathway in absence of ligand [IDA]
- negative regulation of secretion [IDA]
- negative regulation of transcription, DNA-templated [IDA]
- nervous system development [TAS]
- neural crest cell development [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of cardiac muscle cell proliferation [IDA]
- positive regulation of cell adhesion [IDA]
- positive regulation of cell growth [IDA]
- positive regulation of protein tyrosine kinase activity [IDA]
- positive regulation of striated muscle cell differentiation [ISS]
- regulation of protein heterodimerization activity [IDA]
- regulation of protein homodimerization activity [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IDA]
- ventricular cardiac muscle cell differentiation [IDA]
- ventricular trabecula myocardium morphogenesis [IDA]
- wound healing [IDA, TAS]
Gene Ontology Molecular Function- ErbB-3 class receptor binding [IDA, IPI]
- cytokine activity [TAS]
- growth factor activity [IDA, NAS]
- protein binding [IPI]
- protein tyrosine kinase activator activity [IDA]
- receptor binding [IPI]
- receptor tyrosine kinase binding [NAS]
- transcription cofactor activity [IDA]
- transmembrane receptor protein tyrosine kinase activator activity [IC, NAS]
- ErbB-3 class receptor binding [IDA, IPI]
- cytokine activity [TAS]
- growth factor activity [IDA, NAS]
- protein binding [IPI]
- protein tyrosine kinase activator activity [IDA]
- receptor binding [IPI]
- receptor tyrosine kinase binding [NAS]
- transcription cofactor activity [IDA]
- transmembrane receptor protein tyrosine kinase activator activity [IC, NAS]
Gene Ontology Cellular Component
Homo sapiens
PREY
ERBB4
Her4, c-erbB-4, AC167658.1
v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)
GO Process (33)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- cardiac muscle tissue regeneration [IMP]
- cell fate commitment [IDA]
- cell migration [ISO]
- central nervous system morphogenesis [IMP]
- embryonic pattern specification [IMP]
- heart development [IMP]
- lactation [IMP, ISO]
- mammary gland alveolus development [IMP]
- mammary gland epithelial cell differentiation [IMP]
- mitochondrial fragmentation involved in apoptotic process [ISO]
- negative regulation of apoptotic process [ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of muscle cell apoptotic process [ISO]
- nervous system development [IMP]
- neural crest cell migration [IMP]
- olfactory bulb interneuron differentiation [IMP]
- peptidyl-tyrosine phosphorylation [ISO]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of STAT protein import into nucleus [IMP, ISO]
- positive regulation of cardiac muscle cell proliferation [IMP]
- positive regulation of cell migration [ISO]
- positive regulation of cell proliferation [ISO]
- positive regulation of epithelial cell proliferation [ISO]
- positive regulation of glucose import [ISO]
- positive regulation of synaptic transmission, GABAergic [ISO]
- positive regulation of transcription, DNA-templated [IMP, ISO]
- positive regulation of tyrosine phosphorylation of Stat5 protein [IMP, ISO]
- protein autophosphorylation [ISO]
- regulation of cell migration [IMP]
- signal transduction [ISO]
- surfactant homeostasis [ISO]
- synapse maturation [ISO]
- transmembrane receptor protein tyrosine kinase signaling pathway [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Regulation of ErbB-4 endocytosis by neuregulin in GABAergic hippocampal interneurons.
Neuregulin (NRG)/ErbB receptor signaling pathways have recently been implicated in the reversal of long-term potentiation at hippocampal glutamatergic synapses. Moreover, polymorphisms in NRG-1 and ErbB-4 genes have been linked to an increased risk for developing schizophrenia. ErbB-4 is highly expressed at glutamatergic synapses where it binds to PSD-95 via its carboxyl terminal T-V-V sequence. Here we investigated the expression, localization ... [more]
Brain Res. Bull. Jul. 12, 2007; 73(4-6);210-9 [Pubmed: 17562386]
Throughput
- Low Throughput
Additional Notes
- NRG1 peptide added increased surface expression of Erbb2.
Curated By
- BioGRID