BAIT
UBC
2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, Ubb
ubiquitin C
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
OTULIN
C79097, Fam105b, m3Sapc, m7-1Sapc
OTU deubiquitinase with linear linkage specificity
GO Process (8)
GO Function (2)
GO Component (2)
Gene Ontology Biological Process
- canonical Wnt signaling pathway [IDA]
- innate immune response [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of inflammatory response [ISO]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [ISO]
- protein linear deubiquitination [IDA, ISO]
- proteolysis [IMP]
- sprouting angiogenesis [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- LUBAC complex [IDA]
- cytoplasm [IDA, ISO]
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
An Interaction Landscape of Ubiquitin Signaling.
Intracellular signaling via the covalent attachment of different ubiquitin linkages to protein substrates is fundamental to many cellular processes. Although linkage-selective ubiquitin interactors have been studied on a case-by-case basis, proteome-wide analyses have not been conducted yet. Here, we present ubiquitin interactor affinity enrichment-mass spectrometry (UbIA-MS), a quantitative interaction proteomics method that makes use of chemically synthesized diubiquitin to enrich ... [more]
Mol. Cell Mar. 02, 2017; 65(5);941-955.e8 [Pubmed: 28190767]
Throughput
- High Throughput
Additional Notes
- #LPPI
- Chemically synthesized diubiquitin
- Likely protein-protein interaction
- Mouse embryonic stem cells (ESCs)
- Ubiquitin interactor affinity enrichment-mass spectrometry (UbIA-MS)
Curated By
- BioGRID