BAIT
UBC
2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, Ubb
ubiquitin C
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
IKBKG
1110037D23Rik, AI848108, AI851264, AW124339, IKK[g], NEMO, RP23-15J3.1
inhibitor of kappaB kinase gamma
GO Process (7)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- B cell homeostasis [IMP]
- activation of NF-kappaB-inducing kinase activity [IDA]
- cellular response to DNA damage stimulus [ISO]
- establishment of vesicle localization [ISO]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IBA, ISO]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function- K63-linked polyubiquitin binding [IDA]
- linear polyubiquitin binding [ISO]
- peroxisome proliferator activated receptor binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- ubiquitin protein ligase binding [ISO]
- K63-linked polyubiquitin binding [IDA]
- linear polyubiquitin binding [ISO]
- peroxisome proliferator activated receptor binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein homodimerization activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
An Interaction Landscape of Ubiquitin Signaling.
Intracellular signaling via the covalent attachment of different ubiquitin linkages to protein substrates is fundamental to many cellular processes. Although linkage-selective ubiquitin interactors have been studied on a case-by-case basis, proteome-wide analyses have not been conducted yet. Here, we present ubiquitin interactor affinity enrichment-mass spectrometry (UbIA-MS), a quantitative interaction proteomics method that makes use of chemically synthesized diubiquitin to enrich ... [more]
Mol. Cell Mar. 02, 2017; 65(5);941-955.e8 [Pubmed: 28190767]
Throughput
- High Throughput
Additional Notes
- #LPPI
- Chemically synthesized diubiquitin
- Likely protein-protein interaction
- Mouse embryonic stem cells (ESCs)
- Ubiquitin interactor affinity enrichment-mass spectrometry (UbIA-MS)
Curated By
- BioGRID