BAIT
UBC
2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, Ubb
ubiquitin C
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
SERPINE2
B230326M24Rik, PAI-1, PI-7, PI7, PN-1, Spi4
serine (or cysteine) peptidase inhibitor, clade E, member 2
GO Process (29)
GO Function (4)
GO Component (11)
Gene Ontology Biological Process
- blood coagulation [IMP]
- cerebellar granular layer morphogenesis [IMP]
- dense core granule biogenesis [ISO]
- detection of mechanical stimulus involved in sensory perception [IMP]
- innervation [IMP]
- long-term synaptic potentiation [IMP]
- mating plug formation [IMP]
- negative regulation of blood coagulation [ISO]
- negative regulation of cell growth [IGI]
- negative regulation of cell proliferation [IGI]
- negative regulation of endopeptidase activity [IMP]
- negative regulation of peptidase activity [IMP]
- negative regulation of phosphatidylinositol 3-kinase signaling [IGI]
- negative regulation of plasminogen activation [IMP, ISO]
- negative regulation of platelet activation [IMP]
- negative regulation of platelet aggregation [IMP]
- negative regulation of protein catabolic process [IMP, ISO]
- negative regulation of protein processing [IC]
- negative regulation of proteolysis [ISO]
- negative regulation of smoothened signaling pathway [IGI]
- negative regulation of sodium ion transport [IGI, IMP]
- positive regulation of astrocyte differentiation [ISO]
- positive regulation of neuron projection development [ISO]
- regulation of synaptic transmission, glutamatergic [IMP]
- regulation of timing of cell differentiation [IMP]
- response to wounding [IMP]
- secretion by cell [IMP, ISO]
- secretory granule organization [IMP, ISO]
- seminal vesicle epithelium development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
An Interaction Landscape of Ubiquitin Signaling.
Intracellular signaling via the covalent attachment of different ubiquitin linkages to protein substrates is fundamental to many cellular processes. Although linkage-selective ubiquitin interactors have been studied on a case-by-case basis, proteome-wide analyses have not been conducted yet. Here, we present ubiquitin interactor affinity enrichment-mass spectrometry (UbIA-MS), a quantitative interaction proteomics method that makes use of chemically synthesized diubiquitin to enrich ... [more]
Mol. Cell Mar. 02, 2017; 65(5);941-955.e8 [Pubmed: 28190767]
Throughput
- High Throughput
Additional Notes
- #LPPI
- Chemically synthesized diubiquitin
- Likely protein-protein interaction
- Mouse embryonic stem cells (ESCs)
- Ubiquitin interactor affinity enrichment-mass spectrometry (UbIA-MS)
Curated By
- BioGRID