UBC
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ERCC1
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [ISO]
- DNA recombination [IMP, ISO]
- DNA repair [IMP]
- UV protection [IMP]
- cell development [IMP]
- cell proliferation [IMP]
- cellular response to DNA damage stimulus [IMP]
- chromosome organization [IMP]
- double-strand break repair [IMP]
- germ cell development [IMP]
- interstrand cross-link repair [IMP]
- isotype switching [IMP]
- male gonad development [IMP]
- mitotic recombination [ISO]
- multicellular organism growth [IGI, IMP]
- multicellular organismal aging [IMP]
- negative regulation of telomere maintenance [ISO]
- nucleotide-excision repair [IMP, ISO]
- nucleotide-excision repair, DNA incision, 3'-to lesion [ISO]
- nucleotide-excision repair, DNA incision, 5'-to lesion [ISO]
- oogenesis [IMP]
- post-embryonic hemopoiesis [IMP]
- pyrimidine dimer repair by nucleotide-excision repair [IMP]
- replicative cell aging [IMP]
- response to X-ray [IMP]
- response to oxidative stress [ISO]
- spermatogenesis [IMP]
- syncytium formation [IMP]
Gene Ontology Molecular Function- TBP-class protein binding [IPI]
- TFIID-class transcription factor binding [IDA]
- damaged DNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- single-stranded DNA binding [ISO]
- single-stranded DNA endodeoxyribonuclease activity [ISO]
- structure-specific DNA binding [ISO]
- TBP-class protein binding [IPI]
- TFIID-class transcription factor binding [IDA]
- damaged DNA binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- single-stranded DNA binding [ISO]
- single-stranded DNA endodeoxyribonuclease activity [ISO]
- structure-specific DNA binding [ISO]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
An Interaction Landscape of Ubiquitin Signaling.
Intracellular signaling via the covalent attachment of different ubiquitin linkages to protein substrates is fundamental to many cellular processes. Although linkage-selective ubiquitin interactors have been studied on a case-by-case basis, proteome-wide analyses have not been conducted yet. Here, we present ubiquitin interactor affinity enrichment-mass spectrometry (UbIA-MS), a quantitative interaction proteomics method that makes use of chemically synthesized diubiquitin to enrich ... [more]
Throughput
- High Throughput
Additional Notes
- #LPPI
- Chemically synthesized diubiquitin
- Likely protein-protein interaction
- Mouse embryonic stem cells (ESCs)
- Ubiquitin interactor affinity enrichment-mass spectrometry (UbIA-MS)
Curated By
- BioGRID