BAIT
UBC
2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, Ubb
ubiquitin C
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
MAP3K7
B430101B05, C87327, Tak1, RP23-447J12.1
mitogen-activated protein kinase kinase kinase 7
GO Process (14)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
- I-kappaB phosphorylation [IGI]
- MAPK cascade [IDA]
- activation of MAPK activity [IDA]
- angiogenesis [IMP]
- negative regulation of apoptotic signaling pathway [IGI, IMP]
- negative regulation of necroptotic process [IMP]
- negative regulation of reactive oxygen species metabolic process [IMP]
- negative regulation of ripoptosome assembly involved in necroptotic process [IGI]
- neural tube formation [IMP]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IGI]
- positive regulation of JNK cascade [IGI]
- protein phosphorylation [IDA]
- regulation of reactive oxygen species metabolic process [IMP]
- transforming growth factor beta receptor signaling pathway [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
An Interaction Landscape of Ubiquitin Signaling.
Intracellular signaling via the covalent attachment of different ubiquitin linkages to protein substrates is fundamental to many cellular processes. Although linkage-selective ubiquitin interactors have been studied on a case-by-case basis, proteome-wide analyses have not been conducted yet. Here, we present ubiquitin interactor affinity enrichment-mass spectrometry (UbIA-MS), a quantitative interaction proteomics method that makes use of chemically synthesized diubiquitin to enrich ... [more]
Mol. Cell Mar. 02, 2017; 65(5);941-955.e8 [Pubmed: 28190767]
Throughput
- High Throughput
Additional Notes
- #LPPI
- Chemically synthesized diubiquitin
- Likely protein-protein interaction
- Mouse embryonic stem cells (ESCs)
- Ubiquitin interactor affinity enrichment-mass spectrometry (UbIA-MS)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
UBC MAP3K7 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | 2513507 |
Curated By
- BioGRID