BAIT
UBC
2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, Ubb
ubiquitin C
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
TOPORS
AW105885, LUN, TP53BPL, p53BP3/LUN, RP23-9F23.3
topoisomerase I binding, arginine/serine-rich
GO Process (13)
GO Function (6)
GO Component (9)
Gene Ontology Biological Process
- cellular response to DNA damage stimulus [IDA, ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage [ISO]
- intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [IDA]
- maintenance of protein location in nucleus [ISO]
- positive regulation of transcription, DNA-templated [IGI]
- positive regulation of ubiquitin-protein transferase activity [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein K48-linked ubiquitination [ISO]
- protein localization to nucleus [ISO]
- protein monoubiquitination [ISO]
- protein sumoylation [ISO]
- regulation of cell proliferation [IDA]
- ubiquitin-dependent protein catabolic process [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
An Interaction Landscape of Ubiquitin Signaling.
Intracellular signaling via the covalent attachment of different ubiquitin linkages to protein substrates is fundamental to many cellular processes. Although linkage-selective ubiquitin interactors have been studied on a case-by-case basis, proteome-wide analyses have not been conducted yet. Here, we present ubiquitin interactor affinity enrichment-mass spectrometry (UbIA-MS), a quantitative interaction proteomics method that makes use of chemically synthesized diubiquitin to enrich ... [more]
Mol. Cell Mar. 02, 2017; 65(5);941-955.e8 [Pubmed: 28190767]
Throughput
- High Throughput
Additional Notes
- #LPPI
- Chemically synthesized diubiquitin
- Likely protein-protein interaction
- Mouse embryonic stem cells (ESCs)
- Ubiquitin interactor affinity enrichment-mass spectrometry (UbIA-MS)
Curated By
- BioGRID