BAIT
UBC
2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, Ubb
ubiquitin C
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
RBCK1
AL033326, HOIL-1, HOIL-1L, UIP28, Ubce7ip3, RP23-452D3.5
RanBP-type and C3HC4-type zinc finger containing 1
GO Process (12)
GO Function (5)
GO Component (1)
Gene Ontology Biological Process
- T cell receptor signaling pathway [ISO]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of necroptotic process [IGI]
- positive regulation of I-kappaB kinase/NF-kappaB signaling [IMP, ISO]
- positive regulation of NF-kappaB import into nucleus [IMP]
- positive regulation of NF-kappaB transcription factor activity [ISO]
- positive regulation of apoptotic process [IMP]
- positive regulation of extrinsic apoptotic signaling pathway [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein linear polyubiquitination [ISO]
- protein polyubiquitination [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
An Interaction Landscape of Ubiquitin Signaling.
Intracellular signaling via the covalent attachment of different ubiquitin linkages to protein substrates is fundamental to many cellular processes. Although linkage-selective ubiquitin interactors have been studied on a case-by-case basis, proteome-wide analyses have not been conducted yet. Here, we present ubiquitin interactor affinity enrichment-mass spectrometry (UbIA-MS), a quantitative interaction proteomics method that makes use of chemically synthesized diubiquitin to enrich ... [more]
Mol. Cell Mar. 02, 2017; 65(5);941-955.e8 [Pubmed: 28190767]
Throughput
- High Throughput
Additional Notes
- #LPPI
- Chemically synthesized diubiquitin
- Likely protein-protein interaction
- Mouse embryonic stem cells (ESCs)
- Ubiquitin interactor affinity enrichment-mass spectrometry (UbIA-MS)
Related interactions
Curated By
- BioGRID