BAIT
UBC
2700054O04Rik, AI194771, Rps27a, TI-225, Uba52, Ubb
ubiquitin C
GO Process (1)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
PREY
PDPK1
Pdk1, RP23-153H18.1
3-phosphoinositide dependent protein kinase 1
GO Process (23)
GO Function (7)
GO Component (6)
Gene Ontology Biological Process
- activation of protein kinase B activity [ISO]
- calcium-mediated signaling [ISO]
- cell migration [ISO]
- cellular response to epidermal growth factor stimulus [ISO]
- cellular response to insulin stimulus [ISO]
- epidermal growth factor receptor signaling pathway [ISO]
- extrinsic apoptotic signaling pathway [ISO]
- focal adhesion assembly [ISO]
- hyperosmotic response [IDA]
- negative regulation of cardiac muscle cell apoptotic process [IMP]
- negative regulation of protein kinase activity [ISO]
- negative regulation of toll-like receptor signaling pathway [IMP]
- negative regulation of transforming growth factor beta receptor signaling pathway [ISO]
- peptidyl-threonine phosphorylation [ISO]
- positive regulation of establishment of protein localization to plasma membrane [ISO]
- positive regulation of phospholipase activity [ISO]
- positive regulation of release of sequestered calcium ion into cytosol [ISO]
- protein phosphorylation [IDA, ISO]
- regulation of I-kappaB kinase/NF-kappaB signaling [ISO]
- regulation of endothelial cell migration [IMP]
- regulation of mast cell degranulation [IMP]
- signal transduction [TAS]
- type B pancreatic cell development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
An Interaction Landscape of Ubiquitin Signaling.
Intracellular signaling via the covalent attachment of different ubiquitin linkages to protein substrates is fundamental to many cellular processes. Although linkage-selective ubiquitin interactors have been studied on a case-by-case basis, proteome-wide analyses have not been conducted yet. Here, we present ubiquitin interactor affinity enrichment-mass spectrometry (UbIA-MS), a quantitative interaction proteomics method that makes use of chemically synthesized diubiquitin to enrich ... [more]
Mol. Cell Mar. 02, 2017; 65(5);941-955.e8 [Pubmed: 28190767]
Throughput
- High Throughput
Additional Notes
- #LPPI
- Chemically synthesized diubiquitin
- Likely protein-protein interaction
- Mouse embryonic stem cells (ESCs)
- Ubiquitin interactor affinity enrichment-mass spectrometry (UbIA-MS)
Curated By
- BioGRID