BAIT
GRASP
GRP1 (general receptor for phosphoinositides 1)-associated scaffold protein
GO Process (2)
GO Function (4)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
PREY
GABRB2
GARB2
gamma-aminobutyric acid (GABA) A receptor, beta 2
GO Process (12)
GO Function (5)
GO Component (7)
Gene Ontology Biological Process
- cellular response to histamine [IDA]
- chloride transmembrane transport [IMP]
- cochlea development [ISO]
- gamma-aminobutyric acid signaling pathway [TAS]
- inner ear receptor cell development [ISO]
- innervation [ISO]
- negative regulation of neuron apoptotic process [ISO]
- negative regulation of neuron death [ISO]
- neuron development [ISO]
- regulation of neuron apoptotic process [ISO]
- sensory perception of sound [ISO]
- synaptic transmission, GABAergic [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Rattus norvegicus
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Tamalin, a PDZ domain-containing protein, links a protein complex formation of group 1 metabotropic glutamate receptors and the guanine nucleotide exchange factor cytohesins.
In this investigation, we report identification and characterization of a 95 kDa postsynaptic density protein (PSD-95)/discs-large/ZO-1 (PDZ) domain-containing protein termed tamalin, also recently named GRP1-associated scaffold protein (GRASP), that interacts with group 1 metabotropic glutamate receptors (mGluRs). The yeast two-hybrid system and in vitro pull-down assays indicated that the PDZ domain-containing, amino-terminal half of tamalin directly binds to the class ... [more]
J. Neurosci. Feb. 15, 2002; 22(4);1280-9 [Pubmed: 11850456]
Throughput
- Low Throughput
Curated By
- BioGRID