BAIT
TEK
CD202B, TIE-2, TIE2, VMCM, VMCM1
TEK tyrosine kinase, endothelial
GO Process (34)
GO Function (4)
GO Component (11)
Gene Ontology Biological Process
- Tie signaling pathway [IDA]
- angiogenesis [ISS]
- blood coagulation [TAS]
- cell-cell signaling [TAS]
- definitive hemopoiesis [TAS]
- endothelial cell proliferation [ISS]
- heart development [ISS]
- heart trabecula formation [ISS]
- leukocyte migration [TAS]
- negative regulation of angiogenesis [IMP]
- negative regulation of apoptotic process [TAS]
- negative regulation of endothelial cell apoptotic process [ISS]
- negative regulation of inflammatory response [TAS]
- peptidyl-tyrosine phosphorylation [IDA]
- positive regulation of ERK1 and ERK2 cascade [IDA, IMP]
- positive regulation of actin cytoskeleton reorganization [IMP]
- positive regulation of angiogenesis [IDA, IMP]
- positive regulation of endothelial cell migration [IDA, IMP]
- positive regulation of endothelial cell proliferation [TAS]
- positive regulation of focal adhesion assembly [IMP]
- positive regulation of intracellular signal transduction [IMP]
- positive regulation of phosphatidylinositol 3-kinase activity [IMP]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of protein kinase B signaling [IDA, IMP]
- positive regulation of protein phosphorylation [IDA, IMP]
- protein autophosphorylation [IDA]
- protein oligomerization [IDA]
- regulation of endothelial cell apoptotic process [TAS]
- regulation of establishment or maintenance of cell polarity [IMP]
- regulation of vascular permeability [TAS]
- signal transduction [TAS]
- sprouting angiogenesis [IMP]
- substrate adhesion-dependent cell spreading [IMP]
- transmembrane receptor protein tyrosine kinase signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PTK2
FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK
protein tyrosine kinase 2
GO Process (42)
GO Function (8)
GO Component (8)
Gene Ontology Biological Process
- Fc-gamma receptor signaling pathway involved in phagocytosis [TAS]
- angiogenesis [IBA, TAS]
- apoptotic process [TAS]
- axon guidance [TAS]
- blood coagulation [TAS]
- cell motility [TAS]
- cellular component disassembly involved in execution phase of apoptosis [TAS]
- cytoskeleton organization [IBA]
- embryo development [TAS]
- ephrin receptor signaling pathway [IDA]
- epidermal growth factor receptor signaling pathway [IBA]
- establishment of cell polarity [TAS]
- growth hormone receptor signaling pathway [IDA]
- heart morphogenesis [TAS]
- innate immune response [IBA, TAS]
- integrin-mediated signaling pathway [IDA, IMP, TAS]
- negative regulation of anoikis [IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of cell-cell adhesion [IDA]
- netrin-activated signaling pathway [TAS]
- peptidyl-tyrosine autophosphorylation [IBA]
- peptidyl-tyrosine phosphorylation [IDA]
- placenta development [TAS]
- platelet activation [TAS]
- positive regulation of cell migration [IDA]
- positive regulation of cell proliferation [ISS]
- positive regulation of phosphatidylinositol 3-kinase activity [TAS]
- positive regulation of phosphatidylinositol 3-kinase signaling [IMP]
- positive regulation of protein kinase B signaling [IMP]
- positive regulation of protein kinase activity [IMP]
- positive regulation of protein phosphorylation [IMP]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [ISS]
- protein autophosphorylation [IDA]
- regulation of Rho GTPase activity [TAS]
- regulation of cell adhesion mediated by integrin [IDA]
- regulation of cell proliferation [IMP]
- regulation of cell shape [IMP]
- regulation of cytoskeleton organization [TAS]
- regulation of endothelial cell migration [TAS]
- regulation of focal adhesion assembly [TAS]
- regulation of osteoblast differentiation [IMP]
- transforming growth factor beta receptor signaling pathway [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
COMP-Ang1 Potentiates EPC Treatment of Ischemic Brain Injury by Enhancing Angiogenesis Through Activating AKT-mTOR Pathway and Promoting Vascular Migration Through Activating Tie2-FAK Pathway.
Successful recovery from brain ischemia is limited due to poor vascularization surrounding the ischemic zone. Cell therapy with strong angiogenic factors could be an effective strategy to rescue the ischemic brain. We investigated whether cartilage oligomeric matrix protein (COMP)-Ang1, a soluble, stable and potent Ang1 variant, enhances the angiogenesis of human cord blood derived endothelial progenitor cells (hCB-EPCs) for rescuing ... [more]
Exp Neurobiol Mar. 01, 2015; 24(1);55-70 [Pubmed: 25792870]
Throughput
- Low Throughput
Additional Notes
- PLA
Curated By
- BioGRID