BAIT
LMTK2
AATYK2, BREK, KPI-2, KPI2, LMR2, PPP1R100, cprk
lemur tyrosine kinase 2
GO Process (9)
GO Function (5)
GO Component (5)
Gene Ontology Biological Process
- early endosome to late endosome transport [IMP]
- endocytic recycling [IMP]
- negative regulation of catalytic activity [IDA]
- peptidyl-serine phosphorylation [IDA]
- peptidyl-threonine phosphorylation [IDA]
- protein autophosphorylation [IDA]
- protein phosphorylation [IDA]
- receptor recycling [IMP]
- transferrin transport [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
PTPN12
PTP-PEST, PTPG1, tcag7.1075
protein tyrosine phosphatase, non-receptor type 12
GO Process (2)
GO Function (3)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.
Receptor tyrosine kinases (RTKs) and protein phosphatases comprise protein families that play crucial roles in cell signaling. We used two protein-protein interaction (PPI) approaches, the membrane yeast two-hybrid (MYTH) and the mammalian membrane two-hybrid (MaMTH), to map the PPIs between human RTKs and phosphatases. The resulting RTK-phosphatase interactome reveals a considerable number of previously unidentified interactions and suggests specific roles ... [more]
Mol. Cell Jan. 19, 2017; 65(2);347-360 [Pubmed: 28065597]
Throughput
- Low Throughput
Additional Notes
- MYTH assay
Curated By
- BioGRID