BAIT
AATK
AATYK, AATYK1, LMR1, LMTK1, PPP1R77, p35BP
apoptosis-associated tyrosine kinase
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
PPP3CA
CALN, CALNA, CALNA1, CCN1, CNA1, PPP2B
protein phosphatase 3, catalytic subunit, alpha isozyme
GO Process (10)
GO Function (8)
GO Component (4)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- T cell activation [TAS]
- calcineurin-NFAT signaling cascade [IDA]
- cellular response to drug [IDA]
- dephosphorylation [TAS]
- innate immune response [TAS]
- positive regulation of NFAT protein import into nucleus [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- protein dephosphorylation [IDA, NAS]
- response to calcium ion [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- calcineurin complex [IDA, NAS]
- cytoplasm [IDA]
- cytosol [TAS]
- nucleoplasm [IDA, TAS]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.
Receptor tyrosine kinases (RTKs) and protein phosphatases comprise protein families that play crucial roles in cell signaling. We used two protein-protein interaction (PPI) approaches, the membrane yeast two-hybrid (MYTH) and the mammalian membrane two-hybrid (MaMTH), to map the PPIs between human RTKs and phosphatases. The resulting RTK-phosphatase interactome reveals a considerable number of previously unidentified interactions and suggests specific roles ... [more]
Mol. Cell Jan. 19, 2017; 65(2);347-360 [Pubmed: 28065597]
Throughput
- Low Throughput
Additional Notes
- MYTH assay
Curated By
- BioGRID