BAIT
AATK
AATYK, AATYK1, LMR1, LMTK1, PPP1R77, p35BP
apoptosis-associated tyrosine kinase
GO Process (0)
GO Function (1)
GO Component (0)
Gene Ontology Molecular Function
Homo sapiens
PREY
SBF1
CMT4B3, DENND7A, MTMR5, C22:RP4-579N16.2
SET binding factor 1
GO Process (2)
GO Function (2)
GO Component (1)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.
Receptor tyrosine kinases (RTKs) and protein phosphatases comprise protein families that play crucial roles in cell signaling. We used two protein-protein interaction (PPI) approaches, the membrane yeast two-hybrid (MYTH) and the mammalian membrane two-hybrid (MaMTH), to map the PPIs between human RTKs and phosphatases. The resulting RTK-phosphatase interactome reveals a considerable number of previously unidentified interactions and suggests specific roles ... [more]
Mol. Cell Jan. 19, 2017; 65(2);347-360 [Pubmed: 28065597]
Throughput
- Low Throughput
Additional Notes
- MYTH assay
Curated By
- BioGRID