BAIT
ERBB2
CD340, HER-2, HER-2/neu, HER2, MLN 19, NEU, NGL, TKR1
erb-b2 receptor tyrosine kinase 2
GO Process (30)
GO Function (12)
GO Component (7)
Gene Ontology Biological Process
- Fc-epsilon receptor signaling pathway [TAS]
- axon guidance [TAS]
- cell proliferation [TAS]
- cell surface receptor signaling pathway [IDA]
- enzyme linked receptor protein signaling pathway [TAS]
- epidermal growth factor receptor signaling pathway [TAS]
- fibroblast growth factor receptor signaling pathway [TAS]
- innate immune response [TAS]
- neurotrophin TRK receptor signaling pathway [TAS]
- peptidyl-tyrosine phosphorylation [IDA, IGI, TAS]
- phosphatidylinositol 3-kinase signaling [IDA]
- phosphatidylinositol-mediated signaling [TAS]
- positive regulation of MAP kinase activity [IDA]
- positive regulation of Rho GTPase activity [ISS]
- positive regulation of cell adhesion [IDA]
- positive regulation of cell growth [IMP]
- positive regulation of epithelial cell proliferation [IDA]
- positive regulation of protein phosphorylation [ISS]
- positive regulation of transcription from RNA polymerase I promoter [IMP]
- positive regulation of transcription from RNA polymerase III promoter [IDA]
- positive regulation of translation [IMP]
- protein autophosphorylation [IDA]
- protein phosphorylation [TAS]
- regulation of ERK1 and ERK2 cascade [IMP]
- regulation of angiogenesis [NAS]
- regulation of microtubule-based process [IDA]
- signal transduction [IDA]
- signal transduction by phosphorylation [TAS]
- transmembrane receptor protein tyrosine kinase signaling pathway [IDA, TAS]
- wound healing [IDA]
Gene Ontology Molecular Function- ErbB-3 class receptor binding [TAS]
- RNA polymerase I core binding [IDA]
- growth factor binding [IDA]
- identical protein binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein dimerization activity [NAS]
- protein heterodimerization activity [IDA, IPI]
- protein phosphatase binding [IPI]
- protein tyrosine kinase activity [IDA, IGI, TAS]
- transmembrane receptor protein tyrosine kinase activity [IDA]
- transmembrane signaling receptor activity [IDA]
- ErbB-3 class receptor binding [TAS]
- RNA polymerase I core binding [IDA]
- growth factor binding [IDA]
- identical protein binding [IPI]
- protein C-terminus binding [IPI]
- protein binding [IPI]
- protein dimerization activity [NAS]
- protein heterodimerization activity [IDA, IPI]
- protein phosphatase binding [IPI]
- protein tyrosine kinase activity [IDA, IGI, TAS]
- transmembrane receptor protein tyrosine kinase activity [IDA]
- transmembrane signaling receptor activity [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
DUSP18
DSP18, DUSP20, LMWDSP20, bK963H5.1
dual specificity phosphatase 18
GO Process (1)
GO Function (2)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.
Receptor tyrosine kinases (RTKs) and protein phosphatases comprise protein families that play crucial roles in cell signaling. We used two protein-protein interaction (PPI) approaches, the membrane yeast two-hybrid (MYTH) and the mammalian membrane two-hybrid (MaMTH), to map the PPIs between human RTKs and phosphatases. The resulting RTK-phosphatase interactome reveals a considerable number of previously unidentified interactions and suggests specific roles ... [more]
Mol. Cell Jan. 19, 2017; 65(2);347-360 [Pubmed: 28065597]
Throughput
- Low Throughput
Additional Notes
- MYTH assay
Curated By
- BioGRID