BAIT
EPHA7
EHK-3, EHK3, EK11, HEK11
EPH receptor A7
GO Process (12)
GO Function (5)
GO Component (0)
Gene Ontology Biological Process
- brain development [ISS]
- branching morphogenesis of a nerve [ISS]
- ephrin receptor signaling pathway [IDA]
- negative chemotaxis [ISS]
- peptidyl-tyrosine phosphorylation [ISS]
- phosphorylation [ISS]
- positive regulation of neuron apoptotic process [ISS]
- regulation of ERK1 and ERK2 cascade [IDA]
- regulation of cell-cell adhesion [ISS]
- regulation of cysteine-type endopeptidase activity involved in apoptotic process [ISS]
- regulation of peptidyl-tyrosine phosphorylation [IDA]
- regulation of protein autophosphorylation [ISS]
Gene Ontology Molecular Function
Homo sapiens
PREY
MTMR14
C3orf29
myotubularin related protein 14
GO Process (3)
GO Function (1)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
A Global Analysis of the Receptor Tyrosine Kinase-Protein Phosphatase Interactome.
Receptor tyrosine kinases (RTKs) and protein phosphatases comprise protein families that play crucial roles in cell signaling. We used two protein-protein interaction (PPI) approaches, the membrane yeast two-hybrid (MYTH) and the mammalian membrane two-hybrid (MaMTH), to map the PPIs between human RTKs and phosphatases. The resulting RTK-phosphatase interactome reveals a considerable number of previously unidentified interactions and suggests specific roles ... [more]
Mol. Cell Jan. 19, 2017; 65(2);347-360 [Pubmed: 28065597]
Throughput
- Low Throughput
Additional Notes
- MYTH assay
Curated By
- BioGRID