CAPN1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CPEB3
Gene Ontology Biological Process
- 3'-UTR-mediated mRNA destabilization [IDA]
- cellular response to amino acid stimulus [IDA, ISS]
- long-term memory [ISS]
- negative regulation of cytoplasmic translational elongation [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of translation [IDA]
- positive regulation of dendritic spine development [ISS]
- positive regulation of mRNA polyadenylation [ISS]
- positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [IDA]
- positive regulation of nuclear-transcribed mRNA poly(A) tail shortening [IDA]
- positive regulation of translation [ISS]
- regulation of dendritic spine development [ISS]
- regulation of synaptic plasticity [ISS]
- translation [IDA, ISS]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Calpain 2 activated through N-methyl-D-aspartic acid receptor signaling cleaves CPEB3 and abrogates CPEB3-repressed translation in neurons.
Long-term memory requires the activity-dependent reorganization of the synaptic proteome to modulate synaptic efficacy and consequently consolidate memory. Activity-regulated RNA translation can change the protein composition at the stimulated synapse. Cytoplasmic polyadenylation element-binding protein 3 (CPEB3) is a sequence-specific RNA-binding protein that represses translation of its target mRNAs in neurons, while activation of N-methyl-d-aspartic acid (NMDA) receptors alleviates this repression. ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CAPN1 CPEB3 | Biochemical Activity Biochemical Activity An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation. | Low | - | BioGRID | 2298047 |
Curated By
- BioGRID