BAIT
SPTAN1
EIEE5, NEAS, SPTA2
spectrin, alpha, non-erythrocytic 1
GO Process (3)
GO Function (2)
GO Component (7)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SPTBN4
QV, SPNB4, SPTBN3
spectrin, beta, non-erythrocytic 4
GO Process (14)
GO Function (6)
GO Component (14)
Gene Ontology Biological Process
- adult walking behavior [ISS]
- axon guidance [TAS]
- axonogenesis [ISS]
- cardiac conduction [ISS]
- central nervous system projection neuron axonogenesis [ISS]
- clustering of voltage-gated sodium channels [ISS]
- cytoskeletal anchoring at plasma membrane [TAS]
- establishment of protein localization to plasma membrane [ISS]
- negative regulation of heart rate [ISS]
- regulation of peptidyl-serine phosphorylation [ISS]
- regulation of sodium ion transport [ISS]
- sensory perception of sound [ISS]
- transmission of nerve impulse [ISS]
- vesicle-mediated transport [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- PML body [IDA, ISS]
- adherens junction [ISS]
- axon hillock [ISS]
- axon initial segment [ISS]
- cell body fiber [ISS]
- cytoplasm [IDA, ISS]
- cytosol [TAS]
- extracellular vesicular exosome [IDA]
- membrane [IDA]
- neuronal cell body [ISS]
- node of Ranvier [ISS]
- nuclear matrix [IDA, ISS]
- plasma membrane [ISS]
- spectrin [IDA, ISS]
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
Brain proteins interacting with the tetramerization region of non-erythroid alpha spectrin.
The N-terminal region of non-erythroid alpha spectrin (Sp alpha II) is responsible for interacting with its binding partner, beta spectrin, to form functional spectrin tetramers. We used a yeast-two-hybrid system, with an N-terminal segment of alpha spectrin representing the functional tetramerization site, as a bait to screen human brain c-DNA library for proteins that interact with the alpha spectrin segment. ... [more]
Cell. Mol. Biol. Lett. Jul. 04, 2007; 12(4);604-20 [Pubmed: 17607528]
Throughput
- Low Throughput
Curated By
- BioGRID