DM
Gene Ontology Biological Process
- DNA endoreduplication [IMP]
- cell competition in a multicellular organism [IMP]
- cell proliferation [IEP]
- cellular process [IMP]
- embryo development ending in birth or egg hatching [IEP]
- embryonic pattern specification [IGI]
- negative regulation of Notch signaling pathway [IGI]
- neurogenesis [IGI]
- oogenesis [TAS]
- positive regulation of cell growth [TAS]
- positive regulation of developmental growth [IMP]
- positive regulation of growth [IMP, TAS]
- positive regulation of multicellular organism growth [TAS]
- positive regulation of neurogenesis [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of apoptotic process [IMP]
- regulation of autophagy [IMP]
- regulation of cell cycle [TAS]
- regulation of cell growth [IMP]
- regulation of cell size [TAS]
- regulation of imaginal disc-derived wing size [IMP]
- regulation of organ growth [IMP]
- regulation of transcription, DNA-templated [IDA, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MAX
Gene Ontology Biological Process
Gene Ontology Molecular Function
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Max-independent functions of Myc in Drosophila melanogaster.
Myc proteins are powerful proto-oncoproteins and important promoters of growth and proliferation during normal development. They are thought to exercise their effects upon binding to their partner protein Max, and their activities are largely antagonized by complexes of Max with Mnt or an Mxd family protein. Although the biological functions of Myc, Mxd and Mnt have been intensively studied, comparatively ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
DM MAX | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | FlyBase | 2312246 | |
MAX DM | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | FlyBase | - | |
DM MAX | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | FlyBase | - | |
MAX DM | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
DM MAX | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |