LIM1
Gene Ontology Biological Process
- compound eye development [IMP]
- imaginal disc-derived leg morphogenesis [IMP]
- leg disc proximal/distal pattern formation [IMP]
- negative regulation of transcription, DNA-templated [IGI]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of gene expression [IMP]
- regulation of transcription, DNA-templated [ISS]
Gene Ontology Molecular Function
CHI
Gene Ontology Biological Process
- axon guidance [IMP]
- blastoderm segmentation [TAS]
- chaeta development [IMP]
- chaeta morphogenesis [IMP]
- compound eye development [IMP]
- dendrite guidance [IMP]
- imaginal disc-derived wing morphogenesis [IMP]
- nervous system development [IMP]
- phagocytosis [IMP]
- positive regulation of transcription, DNA-templated [IMP]
- regulation of eclosion [IMP]
- regulation of gene expression [IMP]
- transcription, DNA-templated [IMP]
Gene Ontology Molecular Function
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
The transcriptional co-factor Chip acts with LIM-homeodomain proteins to set the boundary of the eye field in Drosophila.
Development involves the establishment of boundaries between fields specified to differentiate into distinct tissues. The Drosophila larval eye-antennal imaginal disc must be subdivided into regions that differentiate into the adult eye, antenna and head cuticle. We have found that the transcriptional co-factor Chip is required for cells at the ventral eye-antennal disc border to take on a head cuticle fate; ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| LIM1 CHI | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | FlyBase | - | |
| LIM1 CHI | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | High | - | BioGRID | - |