BAIT

MIB1

CG5841, D-mib, D-mib1, Dmel\CG5841, Dmib, Mib, dmib1, l(3)72CDa, l(3)72Db, mib1/2, mind-bomb, Dmel_CG5841
mind bomb 1
Drosophila melanogaster
PREY

N

1.1, 16-178, 16-55, Ax, CG3936, CT13012, Chp, Co, Dmel\CG3936, EG:140G11.1, EG:163A10.2, NECD, NICD, RICN, anon-EST:Liang-1.12, clone 1.12, dNotch, fa, l(1)3Cb, l(1)Ax, l(1)N, n[fah], nd, notch, shd, spl, swb, Dmel_CG3936
Notch
GO Process (111)
GO Function (4)
GO Component (15)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Drosophila melanogaster

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Two distinct E3 ubiquitin ligases have complementary functions in the regulation of delta and serrate signaling in Drosophila.

Le Borgne R, Remaud S, Hamel S, Schweisguth F

Signaling by the Notch ligands Delta (Dl) and Serrate (Ser) regulates a wide variety of essential cell-fate decisions during animal development. Two distinct E3 ubiquitin ligases, Neuralized (Neur) and Mind bomb (Mib), have been shown to regulate Dl signaling in Drosophila melanogaster and Danio rerio, respectively. While the neur and mib genes are evolutionarily conserved, their respective roles in the ... [more]

PLoS Biol. Apr. 01, 2005; 3(4);e96 [Pubmed: 15760269]

Throughput

  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
N MIB1
Two-hybrid
Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

High-BioGRID
444415

Curated By